肯尼斯·曼恩博士

研究抽象

研究兴趣

Etiology and Prevention of Loss of Fixation in Cemented Knee Replacements: (PI: KA Mann) The 总体目标 of this study is to provide a mechanistic and functional understanding of the role of mechanical interlock between cement and bone in TKA fixation, and determine if implant fixation can be improved by mitigating the loss of interlock through use of an established drug therapy. 在这场竞争的复兴中, we will develop a cemented tibial replacement model in the rat that recapitulates the cement-bone interlock that occurs in human arthroplasty. We will: 1) investigate alterations in the morphology and 微观 of TKA cement-bone interlock as a function of time with 在活的有机体内 服务, 2) investigate dynamic bone remodeling and cellular response as a function of position in the interlocked construct, 3)确定衰老/骨质疏松对形态学的纵向影响, 微观, and cellular changes of cement-bone interlock for TKA using an ovariectomy (OVX) model, 4) determine if systemic dosing of an antiresorptive agent (zoledronic acid) can prevent loss of TKA interlock in normal and OVX cases, and 5) determine if local dosing of zoledronic acid from PMMA cement in TKA can confer a positive effect as similar to systemic dosing. (NIH资助:2017-2022)

预测转移性疾病患者的骨折. (pi: TA Damron , (曼)原发性肿瘤, 比如乳腺癌和前列腺癌, 转移到骨会引起骨破坏和骨折吗. Predicting whether a bone with metastatic disease will fracture remains a clinical challenge. Clinical scoring systems based on X-ray and patient pain levels are not good predictors for determining which bones require surgical stabilization. We are using Finite Element (FE) modeling of clinical CT scan sets in collaboration with Dr. Timothy Damron to determine activities of daily living that are predictive of fracture.The long term goal is to use FE as a tool to help surgeons decide which patients to stabilize from those that are not at risk of fracture. (鲍德温基金会资助，2016-2019)

放射治疗在增加骨折风险中的作用: (PI: T Damron) Using a murine model of radiation damage to the extremities we are investigating the implications of bony remodeling in terms of structure and fundamental changes to bone material fracture resistance and chemical changes to the bone. We are using biomechanical strength tests and fracture toughness tests to monitor changes in bone structure and material properties with time, 辐射剂量, 和合成代谢, 抗吸收和放射防护治疗. We are also using a combination of voxel-based finite element modeling with material damage models and comparing these to experiments to gain a better understanding of bone ‘brittle’ behavior. (NIH资助:2014-2021 NCE)

Reducing Post-Radiotherapy Bone Fragility Through Orchestrated Cell Survival (PI: ME Oest)采用已建立的有限场小鼠模型, 临床相关的分级照射, this proposal will investigate the natural time course and pharmacologic modulation of RTx-induced bone fragility in terms of local and distant cellular, 组织, 机械函数. 具体来说，目标是1)使用an 在体外 approach to identify RTx-upregulation of cytokine production by primary marrow cells that may regulate bone damage outside the irradiated field, comparing human and murine responses; 2) characterize the progression of marrow progenitor cell damage and recovery cycles post-RTx, including osteoblastic and osteoclastic lineages; 3) determine the efficacy of PTH as a progenitor cell radioprotectant; and 4) evaluate a short, 定制PTH-ZA联合处理祖细胞的放射保护, 正态化矩阵重构, 恢复骨骼强度. 我们的 总体目标 is to identify translatable strategies to preserve post-RTx local and systemic bone quality and strength long-term, compatible with the clinical manifestation of fragility fractures years post-RTx. (NIH资助:2017-2022).

最近的代表刊物

1. Mann KA, Miller MA, Rossow JK, Tatusko ME, Horton JA, Damron TA, Oest ME. Progressive loss of implant fixation in a preclinical rat model of cemented knee arthroplasty. [J]整形外科，2020年12月31日. PMID 33382095
2. barlow CM, Mann KA, Damron TA, Oest ME. Altered mechanical behavior of demineralized bone following therapeutic radiation. [J]骨科杂志，2020. PMID: 32965711
3. Mann KA, Miller MA, Tatusko ME, Oest ME. Similitude of cement-bone micromechanics in cemented rat and human knee replacement. 中华口腔医学杂志，2016,31 (7):529- 537. PMID: 32167182
4. Damron TA, Mann KA. Fracture risk assessment and clinical decision making for patients with metastatic bone disease. 中华口腔医学杂志，2016 (6):1175-1190. PMID 32162711
5. Mandair GS, Oest ME, Mann KA, Morris MD, Damron TA, Kohn DH. Radiation-induced changes to bone composition extend beyond periosteal bone. 骨代表. 2020年3月28日;12:100 . 262. PMID 32258252
6. Mann KA, Miller MA, Amendola RL, Cyndari K, Horton JA, Damron TA, Oest ME. Early changes in cement-bone fixation using a novel rat knee replacement model J骨科 37(10): 2163-2171, 2019. PMID: 31206747
7. Ordway NR, Ash KJ, Miller MA, Mann KA, Hayashi K. A biomechanical comparison of four hip arthroplasty designs in a canine model. 兽医协会骨科创伤. 32(5): 369-375, 2019. PMID 31140184
8. Liu C, Cabahug-Zuckerman P, Stubbs C, Pendola M, Cai C, Mann KA, Castillo AB. Mechanical loading promotes the expansion of primitive osteoprogenitors and organizes matrix and vascular morphology in long bone defects. J骨矿工Res 34(5): 896-910, 2019.
9. Damron TA, Mann KA. Evidence of negative effects of defect size and older patient age by quantitative CT-based 3D image analysis in ultraporous beta-tricalcium phosphate grafted extremity bone defects at one year. 副词. 2018年11月1日:5304215,2018.
10. barlow CM, Mann KA, Damron TA, Oest ME. Limited field radiation therapy results in decreased bone fracture toughness in a murine model. 《推荐最近最火的赌博软件》 13(10):e0204928, 2018.